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Radioactive‐induced tumors by phosphorus‐32 as colloidal compound
Author(s) -
Ubios A. M.,
Silberman F. S.,
Cabrini R. L.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830501)51:9<1605::aid-cncr2820510909>3.0.co;2-2
Subject(s) - medicine , phosphorus 32 , radionuclide , phosphate , phosphorus , nuclear medicine , pathology , radiochemistry , chemistry , biochemistry , nucleotide , physics , organic chemistry , quantum mechanics , gene
Chromic colloidal phosphate labeled with 32 P, which has been proposed for the treatment of several articular diseases, was injected intra‐articularly in the knee joint of adult Wistar rats. After a 270 days minimum latent period, tumors began to appear in the injected zone, to a 70% frequency. Ten lung metastases were detected. In five cases, squamous cell carcinomas were induced in the injected area. The relevance of a sound evaluation of the risk involved in treatments with radioactive isotopes, is discussed.