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Adjuvant postoperative radiation therapy for colorectal carcinoma above the peritoneal reflection I. Sigmoid colon
Author(s) -
Kopelson Gene
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830501)51:9<1593::aid-cncr2820510907>3.0.co;2-8
Subject(s) - medicine , sigmoid colon , radiation therapy , adjuvant , surgery , adenocarcinoma , carcinoma , adjuvant radiotherapy , adjuvant therapy , rectum , chemotherapy , cancer
From 1970–1981, 85 patients had curative sigmoid resections for adenocarcinoma and were eligible for postoperative adjuvant therapy. In a nonrandomized fashion, 10/28 B 2,3 and 7/28 C 2,3 patients received postoperative pelvic radiation therapy (4500–5100 rad/5–6 weeks). Compared to the 39 B 2,3 or C 2,3 patients not receiving adjuvant pelvic irradiation, those 17 who did demonstrated retrospectively an improved pelvic regional disease control rate (70 versus 91%) and an improved five‐year survival for irradiated B 2,3 cases versus unirradiated B 2,3 cases. (100 versus 64%, P < 0.05). C 2,3 cases showed no survival advantage for pelvic irradiation. This retrospective analysis suggests that for sigmoid carcinoma patients, postoperative adjuvant pelvic irradiation may be beneficial in terms of improved regional disease control rates for B 2,3 and C 2,3 cases and also improved survival for B 2,3 cases.