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Differentiation of growth patterns of early gastric carcinoma determined by cytophotometric0 DNA analysis
Author(s) -
Inokuchi Kiyoshi,
Kodama Yoshifumi,
Sasaki Osamu,
Kamegawa Takahisa,
Okamura Takeshi
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830315)51:6<1138::aid-cncr2820510627>3.0.co;2-e
Subject(s) - dna , nuclear dna , carcinoma , gastric carcinoma , pathology , biology , medicine , cancer , genetics , gene , mitochondrial dna
Cell nuclear DNA content was microspectrophotometrically measured in 60 cases of early and six of advanced gastric carcinoma. DNA distribution pattern was classified into Types I, II and III, according to the degree of dispersion on the DNA histogram. Five of 6 cases of the advanced carcinomas were Type III. In early carcinoma, the majority of Super (superfically spreading) type were Type II, while all of Pen A (expansively penetrating growth) type were Type III. In Pen B (infiltratively penetrating growth)type, six of ten cases were Type II and the other four were Type III. Thus, there was a distinct difference in the DNA pattern between Super and Pen Types, i.e., the DNA analysis reflected these growth types. Since about 20% of those with small mucosal carcinomas, not classifiable into the Super or the Pen types presented Type III, the cytophotometric DNA analysis should be useful in the detection of Pen A like carcinoma, in its early stage. The development from early stage. The development from early to advanced carcinoma was discussed in terms of the similarity of the DNA histogram patterns.