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Suppression of one monoclonal immunoglobulin in the presence of another in multiple myeloma: Evidence for benign B‐cell neoplasia
Author(s) -
Keshgegian Albert A.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830315)51:6<1097::aid-cncr2820510621>3.0.co;2-w
Subject(s) - clone (java method) , multiple myeloma , polyclonal antibodies , monoclonal , monoclonal gammopathy of undetermined significance , myeloma protein , medicine , antibody , monoclonal antibody , gammopathy , neoplasm , immunoglobulin g , immunology , microbiology and biotechnology , pathology , biology , dna , genetics
The case of a 77‐year‐old man with two monoclonal proteins, IgG lambda and IgG kappa, is presented. The IgG kappa protein increased in concentration, and, after two years, overt multiple myeloma developed with anemia and suppression of polyclonal immunoglobulins. The IgG lambda protein at first remained constant, but disappeared when overt myeloma developed. The disappearance of the IgG lambda protein suggests suppression of one neoplastic immunoglobulin clone by another, more aggressive, clone. This indicates that idiopathic monoclonal gammopathy can result from a benign neoplasm of B‐cells that is responsive to regulatory factors and is not an early stage of myeloma.