Premium
Glucagonomas: Ultrastructure and immunocytochemistry
Author(s) -
Warner Thomas F. C. S.,
Block Margaret,
Hafez G. Reza,
Mack Eberhard,
Lloyd Ricardo V.,
Bloom Stephen R.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830315)51:6<1091::aid-cncr2820510620>3.0.co;2-g
Subject(s) - glucagonoma , glucagon , immunocytochemistry , medicine , ultrastructure , pathology , pancreas , pancreatic polypeptide , insulin
Pancreatic tumors harboring glucagon immunoreactive cells were found in four patients with diabetes mellitus. Alpha‐cell (glucagon) granules were present in three tumors; pancreatic polypeptide (PP) immunoreactive cells were detected in two. In two patients the tumors were malignant and one of these had the glucagonoma syndrome; the other was a member of a family with MEN‐type I syndrome. These cases illustrate three clinical subtypes of glucagonoma.