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Epstein‐barr virus, fatal infectious mononucleosis, and Hodgkin's disease in siblings
Author(s) -
Veltri Robert W.,
Shah Shiela H.,
McClung James E.,
Klingberg William G.,
Sprinkle Philip M.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830201)51:3<509::aid-cncr2820510324>3.0.co;2-b
Subject(s) - mononucleosis , medicine , virus , serology , disease , epstein–barr virus infection , epstein–barr virus , lymphoma , daughter , immunology , virology , pathology , antibody , biology , evolutionary biology
Epstein‐Barr virus (EBV) infection in a family resulted in a fatal disseminated heterophil negative infectious mononucleosis syndrome in a nine‐year‐old girl. This was followed closely by a similar disease process in her six‐year‐old brother which evolved over a one‐year period into Stage IIIB Hodgkin's disease. Finally, three years after the index EBV case in the daughter, the mother was diagnosed with a non‐Burkitt's‐type undifferentiated lymphoma that proved rapidly fatal. The EBV involvement in the sister and brother was well documented serologically and virologically. The pathologic diagnosis was established and confirmed by more than one pathologist. There was no obvious evidence for either a specific or general immune defect in any of the family members tested. The progression of the six‐year‐old boy's EBV infection from a benign, yet disseminated disease process into a histopathologically confirmed case of Hodgkin's disease offers a strong suggestion that this virus was not behaving solely as a passenger. Especially relevant is the fact that the boy never fully recovered from his EBV infection and essentially became persistently infected with the virus as evidenced by his EBV‐EA serology and virology results.