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Malignant brenner tumor of the ovary: Electron microscopic study of a case responsive to radiation and chemotherapy
Author(s) -
Haid Max,
Victor Thomas A.,
WeldonLinne C. Michael,
Danforth David N.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830201)51:3<498::aid-cncr2820510323>3.0.co;2-b
Subject(s) - cyclophosphamide , medicine , chemotherapy , ovary , pathology , amethopterin , radiation therapy , ultrastructure , doxorubicin , metaplasia , radiology , methotrexate
A patient with malignant Brenner tumor of the ovary is presented. The tumor responded to combined therapy with radiation plus doxorubicin + cyclophosphamide despite earlier failure on a single alkylating agent (levophenylalanine mustard). The patient next exhibited a brief response to chemotherapy with hexamethylmelamine + cyclophosphamide + amethopterin + 5‐fluorouracil. The histologic findings and ultrastructure of the tumor are discussed in detail. The morphologic features are consistent with the proposed origin of Brenner tumors from coelomic epithelium through a process of secondary urothelial metaplasia.