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Osteosarcoma: Intra‐arterial treatment of the primary tumor with cis‐diammine‐dichloroplatinum II (CDP): Angiographic, pathologic, and pharmacologic studies
Author(s) -
Jaffe Norman,
Knapp John,
Chuang Vincent P.,
Wallace Sidney,
Ayala Alberto,
Murray John,
Cangir Ayten,
Wang Alexander,
Benjamin Robert S.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830201)51:3<402::aid-cncr2820510308>3.0.co;2-p
Subject(s) - medicine , osteosarcoma , chemotherapy , sarcoma , primary tumor , surgery , radiology , pathology , cancer , metastasis
Intra‐arterial CDP was utilized to treat the primary tumor in 11 pediatric patients with osteosarcoma and in one with malignant fibrous histiocytoma. The investigation commenced with a phase I‐II pilot study in four osteosarcoma patients. A dose of 150 mg/m 2 was found to be safe and effective in producing a clinical response. This was followed by a definitive study in the remaining seven osteosarcoma patients and in the one malignant fibrous histiocytoma patient. The results were assessed by specific clinical, pharmacologic, radiographic and pathologic criteria. The overall response in the definitive study was 50% with two patients exhibiting total tumor destruction. The success of intra‐arterial CDP was attributed to its ability to achieve high local drug concentration and tumor penetration. This was demonstrated by pharmacologic studies.