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Vincristine, adriamycin, and mitomycin (VAM) therapy for previously treated breast cancer: A preliminary report
Author(s) -
Oster Martin W.,
Park Young
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830115)51:2<203::aid-cncr2820510205>3.0.co;2-0
Subject(s) - medicine , vincristine , regimen , chemotherapy , toxicity , mitomycin c , breast cancer , oncology , surgery , metastatic breast cancer , cyclophosphamide , cancer
Fifteen patients with metastatic breast cancer previously treated with chemotherapy were treated with a regimen consisting of vincristine, Adriamycin, and mitomycin. Eleven patients (73%) responded with three complete and eight partial responses. The median duration of response was eight months. While all four nonresponders died within five months, the median duration of survival of responders was 18 months. Toxicity was significant but tolerable. Thus, this preliminary report suggests that this regimen is active in advanced previously treated breast cancer, providing meaningful remissions with acceptable toxicity.