Premium
Copper and copper‐binding protein in fibrolamellar liver cell carcinoma
Author(s) -
Lefkowitch Jay H.,
Muschel Ruth,
Price John B.,
Marboe Charles,
Braunhut Susan
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830101)51:1<97::aid-cncr2820510120>3.0.co;2-1
Subject(s) - copper , hepatocellular carcinoma , malignancy , cholestasis , medicine , pathology , carcinoma , liver cell , cell , staining , immunohistochemistry , cancer research , hepatic carcinoma , biochemistry , biology , chemistry , organic chemistry
Analysis of tissue from a recent case of fibrolamellar liver cell carcinoma by several staining and spectrophotometrc methods demonstrated elevated copper and copper‐binding protein (CBP) in malignant hepatocytes. Production of CBP has not previously been described for this or any other type of hepatocellular carcinoma. Identification of CBP in liver cell carcinoma adds further evidence that this protein is a normal synthetic product of liver cells which may reappear in chronic cholestasis or hepatic malignancy. The mechanism of disturbed copper homeostasis in this case is uncertain.