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Use of a human tumor cloning system to screen retinoids for antineoplastic activity
Author(s) -
Cowan John D.,
Von Hoff Daniel D.,
Dinesman Allen,
Clark Gary
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830101)51:1<92::aid-cncr2820510119>3.0.co;2-r
Subject(s) - retinoid , retinoic acid , cloning (programming) , cancer research , medicine , retinol , microbiology and biotechnology , biochemistry , endocrinology , biology , gene , vitamin , computer science , programming language
Retinoid analogs are being actively evaluated as antitumor agents in man. A human tumor cloning system was used to assess the antineoplastic activity of all‐ trans ‐retinoic acid, all‐ trans ‐retinol and 13‐ cis ‐retinoic acid. The effect of retinoids on the formation of tumor colony forming units (T‐CFU) was surveyed for 67 different human tumors. These analogs showed minor activity in a variety of neoplasms. The decrease in T‐CFU varied between histologic tumor types and between tumor of the same type. No significant difference between retinoid analogs was noted.