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The non‐Hodgkin's lymphomas I. A retrospective clinical and pathologic analysis of 499 cases diagnosed between 1958 and 1969
Author(s) -
Straus David J.,
Filippa Daniel A.,
Lieberman Philip H.,
Koziner Benjamin,
Thaler H. Tzvi,
Clarkson Bayard D.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830101)51:1<101::aid-cncr2820510121>3.0.co;2-w
Subject(s) - medicine , lymphoma , retrospective cohort study , biopsy , overall survival , working formulation , survival rate , non hodgkin's lymphoma , surgery
A retrospective clinical and histopathological review was made of 499 previously untreated cases of non‐Hodgkin's lymphoma with adequate initial biopsy material diagnosed at Memorial Hospital between 1958 and 1969. Three hundred‐eighty‐four cases (77%) had diffuse, 104 (21%) nodular, nine (2%) nodular and diffuse, and two (< 1%) unclassifiable histologic types. Overall median survival was 16 months, and 79% of the patients died with lymphoma. For all treatments, survival of responding patients was the same as that of nonresponders, a reflection of the palliative approach. Significant differences in survival were found between patients in the various Ann Arbor stages. Median survival was 42 months for the nodular group and 11.5 months for the diffuse ( P < 0.001). The ten‐year survival was 12% for the diffuse and 22% for the nodular patients. The overall difference in survival was due to early deaths in the diffuse group. Long‐term follow‐up is necessary to appreciate the usual fatal course of patients with all types of non‐Hodgkin's lymphomas treated conservatively.