Premium
Chronic lymphocytic leukemia a review of 745 cases and assessment of clinical staging
Author(s) -
Skinnider Leo F.,
Tan Len,
Schmidt Joanne,
Armitage George
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19821215)50:12<2951::aid-cncr2820501241>3.0.co;2-s
Subject(s) - medicine , stage (stratigraphy) , chronic lymphocytic leukemia , anemia , staging system , leukemia , surgery , pediatrics , cancer , paleontology , biology
Review of 745 cases of chronic lymphocytic leukemia show that clinical staging by either the Rai or Binet method is very valuable in assessment of patients at the time of diagnosis. There is a marked decrease in survival with advancing stage (19.9 years median survival for Rai Stage 0, and 2.5 years and 2.7 years for Rai Stages 3 and 4, respectively). The definition of anemia as Hb < 11 g/dl as in the Rai staging method appears to give slightly better discrimination among the stages than the Binet staging procedure. Patients with splenomegaly alone (Binet Stage 2), however, form a small but distinct group that should be recognized. There is little to be gained by subdividing further according to size of the lymph nodes.