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Possible pulmonary toxicity secondary to vinblastine
Author(s) -
Konits Philip H.,
Aisner Joseph,
Sutherland John C.,
Wiernik Peter H.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19821215)50:12<2771::aid-cncr2820501213>3.0.co;2-t
Subject(s) - vinblastine , medicine , pulmonary toxicity , pulmonary fibrosis , clearance , interstitial lung disease , chemotherapy , toxicity , lung , pneumonitis , drug , pharmacology , pathology , urology
A number of chemotherapeutic agents and multiple other drugs are known to produce interstitial pneumonitis and pulmonary fibrosis. It is important to realize which agents can produce or interact with other drugs to produce this complication. Two patients receiving combination chemotherapy with mitomycin‐C and vinblastine developed diffuse interstitial pulmonary infiltrates in temporal relationship to vinblastine administration. The infiltrates cleared but recurred and produced chronic pulmonary changes. Since it is likely that the vinblastine either caused or contributed to the pulmonary damage, this drug must be considered among the antineoplastic agents which can cause or contribute to interstitial pulmonary disease.