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Results of LSA 2 ‐L 2 therapy in 26 children with non‐hodgkin's lymphoma
Author(s) -
Pichler Eva,
Jürgenssen OlafArne,
Radaszkiewicz Thaddäus,
Reinartz Gisela,
Mutz Ingomar,
Urban Christian,
Krepler Paul,
Schmidmeier Waltraud,
Becker Hans,
Kundi Michael
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19821215)50:12<2740::aid-cncr2820501208>3.0.co;2-l
Subject(s) - medicine , lymphoma , stage (stratigraphy) , disease , rappaport , lymphoblastic lymphoma , mediastinum , pediatrics , surgery , immunology , t cell , paleontology , philosophy , theology , immune system , biology
Twenty‐six children with non‐Hodgkin's lymphoma (NHL), 17 boys and nine girls, were treated with the LSA 2 ‐L 2 protocol. Seven children had Stage I or II, 16 Stage III and three Stage IV according to Murphy's staging system. Eight children had their primaries in peripheral lymph nodes, eight in the abdomen, six in the mediastinum and four in other sites. All tumors were classified histologically according to four different classifications. Overall disease‐free actuarial survival is 53.6%. Complete responders show a disease‐free survival of 77.8%. Fourteen children survived for 9–56 months. Included are all seven children with Stage I or II who survive irrespective of histologic type of the tumor. Of the remaining 12 children in Stage III or IV three children died in remission and nine of progressive disease. Eight of these nine patients did not attain complete remission. Whereas four of five children with the convoluted type of NHL survive, four of five patients with the Burkitt's type (small noncleaved follicle center cell lymphomas) died of progressive disease. According to Rappaport's classification, four of six children with diffuse undifferentiated lymphoma (DUL) are dead due to tumor progression. Considering the classification of lymphoblastic lymphomas introduced by Nathwani et al. , 23 five of seven children suffering from lymphoblastic lymphomas but only two of eight children with nonlymphoblastic lymphomas belong to the survivors. Therefore histologic findings do hold prognostic sigicance in our series of children with NHL.