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Properdin factor B and acute lymphocytic leukemia (ALL)
Author(s) -
Budowle Bruce,
Acton Ronald T.,
Barger Bruce O.,
Blackstock Rebecca,
Crist William,
Go Rodney C. P.,
Humphrey G. Bennett,
Ragab Abdel,
Roper Maryanne,
Vietti Teresa,
Dearth James
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19821201)50:11<2369::aid-cncr2820501123>3.0.co;2-s
Subject(s) - properdin , allele , medicine , locus (genetics) , chronic lymphocytic leukemia , immunology , phenotype , immune system , complement factor b , risk factor , leukemia , gene , genetics , complement system , biology
One hundred‐sixty‐four ALL patients were compared to 545 controls for differences in phenotype and gene frequencies at the Properdin factor B locus. In addition, 90 of the ALL patients were immune phenotyped. A significant association with the Bf F allele and ALL was found, resulting in an estimated relative risk of 3.62. There was no difference in the Bf S phenotype between ALL patients and controls. However, those homozygous for the Bf S allele are at a significantly low risk of 0.30 for developing ALL. ALL patients with a non‐B/T cell type were 2.5 times more likely to be Bf SS homozygotes; in contrast, those patients with the pre‐B cell type were 2.5 more likely to be Bf FF homozygotes. These data suggest association of the Bf locus with an ALL protection and/or susceptibility gene(s).