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Diagnostic value of tumoral markers in serous effusions. Carcinoembryonic antigen, alpha 1 ‐acidglycoprotein, alpha‐fetoprotein, phosphohexose isomerase, and Beta 2 ‐microglobulin
Author(s) -
MartinezVea, A.,
Gatell J. M.,
Segura F.,
Heiman C.,
Elena M.,
Ballesta A. M.,
Mundo M. Ribas
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19821101)50:9<1783::aid-cncr2820500923>3.0.co;2-v
Subject(s) - medicine , carcinoembryonic antigen , beta 2 microglobulin , serous fluid , malignancy , effusion , pathology , peritoneal effusion , ascites , gastroenterology , cancer , surgery
In order to discriminate between benign and malignant effusions, the value of carcinoembryonic antigen (CEA), alpha 1 ‐acidglycoprotein (AGP), alpha‐fetoprotein (AFP), phosphohexose isomerase (PHI), and beta 2 ‐microglobulin (B 2 M) has been estimated in serous effusions in a group of 106 patients, 30 with a malignant and 76 with a benign effusion. Mean CEA and AGP levels in malignant effusions were significantly higher than in benign effusions; no significant differences of mean PHI, AFP and B 2 M levels of benign and malignant effusions were found. CEA level estimations were useful for confirming malignancy in 27% of malignant effusions but in only 7.5% of all effusions, and AGP and PHI for excluding it in 37.5 and 36.0% of all effusions, respectively. With the combination of CEA with AGP or PHI, a correct diagnosis was achieved in only 45 and 44% of all effusions, respectively. The combination of AFP or B 2 M with CEA, AGP or PHI did not improve the discriminative value for differentiating malignant and benign effusions. Cancer 50:1783–1788, 1982.