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Prolonged intermittent adjuvant chemotherapy with CCNU and hydroxyurea after resection of carcinoma of the lung
Author(s) -
Shields Thomas W.,
Higgins George A.,
Humphrey Edward W.,
Matthews Mary J.,
Keehn Robert J.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19821101)50:9<1713::aid-cncr2820500910>3.0.co;2-b
Subject(s) - medicine , chemotherapy , adjuvant , oncology , carcinoma , adjuvant chemotherapy , lung , resection , surgery , cancer , breast cancer
Eight hundred sixty‐five patients with a microscopically curative resection for carcinoma of the lung were accepted for study, none of whom were excluded from analysis. Adjuvant therapy was randomly assigned about the tenth to 14th postoperative day; 432 patients (treated) were to receive CCNU and hydroxyurea for one year, while 433 patients (controls) were to receive no adjuvant therapy. Toxic reactions to therapy were reported, but only 1% were severe enough to require stopping therapy. No evidence of improved survival or delayed recurrence of disease was seen in treated patients as a whole or when examined by cell type and by postsurgical TNM category. On the contrary, survival beyond the second year of follow‐up may have been impaired by the drugs when administered to patients without evidence of tumor spread to the lymph nodes. Cancer 50:1713‐1721, 1982.