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Radionuclide bone scan, radiographic bone survey, and alkaline phosphatase. Studies of limited value in asymptomatic patients with ovarian carcinoma
Author(s) -
Mettler Fred A.,
Christie James H.,
Crow Neil E.,
Garcia Jose F.,
Wicks Jeffrey D.,
Bartow Sue A.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19821015)50:8<1483::aid-cncr2820500806>3.0.co;2-r
Subject(s) - medicine , asymptomatic , stage (stratigraphy) , radiography , alkaline phosphatase , ovarian carcinoma , radiology , carcinoma , nuclear medicine , bone pain , bone disease , ovarian cancer , pathology , cancer , osteoporosis , paleontology , biochemistry , chemistry , biology , enzyme
Bone scans or skeletal surveys were obtained in 104 patients with ovarian carcinoma. No metastases were identified at staging in the 43 patients with Stage I or II disease. Four patients in the entire series had osseous metastases. Three of the 40 patients with Stage III epithelial ovarian carcinoma had osseous metastases at the time of staging. All of these were Grade III lesions. One Stage I, Grade III patient demonstrated osseous metastases two years after initial diagnosis. None of the four patients with osseous metastases had an elevated alkaline phosphatase; three of the four had bone pain. Based on these results, it is suggested that radiographic bone survey and radionuclide bone scans are not indicated as screening procedures in asymptomatic patients with ovarian carcinoma.