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Acute nonlymphoblastic leukemia. Prognostic factors in adults with long‐term follow‐up
Author(s) -
Passe Sharon,
Miké Valerie,
Mertelsmann Roland,
Gee Timothy S.,
Clarkson Bayard D.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19821015)50:8<1462::aid-cncr2820500804>3.0.co;2-1
Subject(s) - medicine , complete remission , cancer , multivariate analysis , leukemia , disease , surgery , pediatrics , chemotherapy
Seventy‐nine adult patients with acute nonlymphoblastic leukemia (ANLL) were treated on the L‐6 protocol at Memorial Sloan‐Kettering Cancer Center between May 1970 and January 1974. Forty‐two patients achieved a complete remission (CR) and nine of these are still disease free, with a minimum of seven years of follow‐up. An extensive statistical analysis has been carried out on a large number of pretreatment and treatment characteristics to identify factors related to CR and remission duration. Multivariate regression techniques yielded as favorable characteristics associated with CR, in order of importance: young age at diagnosis, the presence of Auer rods at diagnosis, and treatment with Pseudomonas vaccine. A regression model for remission duration identified as favorable prognostic factors for long‐term remission: at most two courses of induction therapy, an intermediate age range, and a low platelet count at diagnosis.