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Central nervous system involvement in mycosis fungoides. Diagnosis, treatment and literature review
Author(s) -
Bodensteiner David C.,
Skikne Barry
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820915)50:6<1181::aid-cncr2820500625>3.0.co;2-p
Subject(s) - mycosis fungoides , medicine , clearance , methotrexate , radiation therapy , central nervous system , dermatology , surgery , pathology , lymphoma , urology
A 58‐year‐old man with mycosis fungoides developed headache, back pain, and dorsal column signs. A diagnosis of central nervous system (CNS) involvement by mycosis fungoides was made on examination of his spinal fluid. In this patient, cranial and local radiotherapy and aggressive treatment with intrathecal methotrexate cleared the leukemic cells from his CNS, and maintenance therapy with intrathecal methotrexate has resulted in an 18‐month remission.