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Alterations of creatine kinase isoenzymes in colon washings from patients with colonic and rectal diseases
Author(s) -
Bereznitsky Simon,
Lobstein Otto E.,
Ko SungTao,
Weinstock Albert
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820915)50:6<1177::aid-cncr2820500624>3.0.co;2-b
Subject(s) - medicine , rectum , mucus , gastroenterology , colorectal cancer , pathology , hemorrhoids , mucin , cancer , biology , ecology
Mucus samples obtained from 61 patients with different types of colon and rectal disease were assayed for CK isoenzyme fractionation. Twelve additional patients without evidence of such diseases were used as reference subjects. The diseases surveyed were hemorrhoids, proctocolitis, polyps, and cancer of the colon and rectum. The CK BB fraction was predominant in the mucus of the reference subjects and in mild cases of hemorrhoids and polyps. With inflammation or degeneration of the colonic mucosa, the percent CK BB decreased and the percent of CK MM increased. It is speculated that the increased CK MM possibly derives from increased permeability or degeneration of the colonic wall, permitting plasma CK MM to admix with the mucus. Muein CK isoenzyme fractionation may be useful in assessing the pathogenesis of colonic and rectal diseases, as a marker to monitor the efficacy of the therapeutic regimen, and as a technique for monitoring conversion of a premalignant process into a malignant one.