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Germ cell malignancies of the ovary. Treatment with vinblastine, actinomycin D, bleomycin and cisplatin containing chemotherapy combinations
Author(s) -
Bradof James E.,
Hakes Thomas B.,
Ochoa Manuel,
Golbey Robert
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820915)50:6<1070::aid-cncr2820500609>3.0.co;2-m
Subject(s) - vinblastine , bleomycin , cisplatin , medicine , chemotherapy , adjuvant , ovary , oncology , disease , germ cell tumors , combination chemotherapy , cancer research
Seventeen patients with malignant ovarian germ cell tumors were treated with vinblastine, actinomycin D, bleomycin and cisplatin containing combinations. Many of these patients were heavily pretreated. Thirteen patients had objectively measurable disease and ten (77%) had an objective response (CR or PR). Four patients had nonmeasurable disease or were treated in an adjuvant setting and all remain without evidence of disease. Extensive disease and poor performance status were poor prognostic factors. Induction portions of these treatment programs which contained cisplatin appeared most effective. Maintenance portions without cisplatin appeared less effective.