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The palliation of symptomatic osseous metastases final results of the study by the radiation therapy oncology group
Author(s) -
Tong Daphne,
Gillick Laurence,
Hendrickson Frank R.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820901)50:5<893::aid-cncr2820500515>3.0.co;2-y
Subject(s) - medicine , pain relief , radiation therapy , palliative care , chemotherapy , palliative treatment , dose fractionation , surgery , oncology , nursing
Different dose fractionation irradiation schedules have been evaluated in a randomized Radiation Therapy Oncology Group (RTOG) study to determine their palliative effectiveness in patients with osseous metastases. The frequency, promptness and duration of pain relief were utilized as measures of response. Ninety percent of patients experienced some relief of pain and 54% achieved eventual complete pain relief. Important prognosticators included the initial pain score and the site of the primary lesions. Administration of steroid or chemotherapy during the one‐month on‐study period did not influence the frequency of pain relief. The low‐dose, short‐course schedules were as effective as the high‐dose protracted programs.