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Noncardiogenic pulmonary edema following injection of methotrexate into the cerebrospinal fluid
Author(s) -
Bernstein Mark L.,
Sobel Daniel B.,
Wimmer Robert S.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820901)50:5<866::aid-cncr2820500510>3.0.co;2-6
Subject(s) - medicine , methotrexate , pulmonary edema , respiratory distress , cerebrospinal fluid , edema , anesthesia , pneumonitis , lung , pathology
The most common pulmonary disorder induced by methotrexate is a gradually developing interstitial pneumonitis. The associated clinical manifestations include slowly progressive dyspnea and nonproductive cough, with extensive radiographic changes. One case has been reported following intrathecal methotrexate administration; the remainder occurred after either intravenous or oral therapy. We report two cases of rapidly developing respiratory distress following the administration of methotrexate into the cerebrospinal fluid. The clinical courses, radiologic findings, and, in one patient, the pathologic nature, are consistent with noncardiogenic pulmonary edema.