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Multiple squamous‐cell carcinomas in fanconi's anemia
Author(s) -
Kennedy Alexander W.,
Hart William R.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820815)50:4<811::aid-cncr2820500432>3.0.co;2-i
Subject(s) - fanconi anemia , medicine , basal cell , cancer , tongue , anemia , pathology , vulva , aplastic anemia , cancer research , bone marrow , dna repair , biology , dna , genetics
Fanconi's anemia is one of the chromosome instability syndromes that may predispose to the development of cancer. A 20‐year‐old woman is reported in whom microinvasive squamous‐cell carcinomas of the vulva and tongue developed sequentially. The clinicopathologic findings of 13 other cases of Fanconi's anemia associated with squamous‐cell carcinomas are reviewed. Anogenital and oral mucosal surfaces appear to be sites of predilection for these cancers. Patients with relatively mild bone marrow problems or the preanemic phase of the illness who are able to survive several decades appear to be at greatest risk for the development of squamous‐cell carcinoma.