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Acute leukemia following intensive therapy for small‐cell carcinoma of the lung
Author(s) -
Markman Maurie,
Pavy Michael D.,
Abeloff Martin D.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820815)50:4<672::aid-cncr2820500409>3.0.co;2-y
Subject(s) - medicine , pancytopenia , radiation therapy , bone marrow , chemotherapy , leukemia , sideroblastic anemia , oncology , small cell carcinoma , carcinoma , acute leukemia , lung cancer , lung
Acute leukemia developed in two patients who had been in remission for longer than two years after receiving intensive combination chemotherapy and radiotherapy for small‐cell carcinoma of the lung. Both patients were first seen with pancytopenia and sideroblastic anemia with increased erythroblasts in the bone marrow. Chromosomal abnormalities were demonstrated in both cases. It is likely that the intensive combination therapy given to these patients caused transformation of bone marrow stem cells, resulting in acute leukemia.