Premium
Autopsy findings in 154 patients with germ cell tumors of the testis
Author(s) -
Bredael Jacques J.,
Vugrin Davor,
Whitmore Willet F.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820801)50:3<548::aid-cncr2820500327>3.0.co;2-2
Subject(s) - medicine , autopsy , seminoma , lung , metastasis , mediastinum , choriocarcinoma , pathology , lymph node , germ cell tumors , incidence (geometry) , dissection (medical) , respiratory failure , cancer , radiology , chemotherapy , physics , optics
Autopsy findings are reviewed in 154 patients treated for germ cell tumors of the testis. Of the patients with apparently pure seminoma, 44% had autopsy evidence of nonseminomatous metastases. For all tumor types, the most common sites of distant metastasis were lung (89%), liver (73%), brain (31%), and bone (30%). There was a high incidence of brain metastases in choriocarcinoma and of bone metastases in seminoma. Brain, liver, and bone metastases were late occurrences in the course of the disease and were almost always associated with involvement of other sites. Recurrences in the retroperitoneal area after lymph node dissection occurred mainly in those who had had retroperitoneal lymph node metastases. No difference in site or frequency of metastases was apparent in autopsied patients treated before or after introduction of platinum containing regimens. Respiratory failure, secondary to lung metastases, was the most common cause of death. Of the autopsied patients, 6% died of iatrogenic causes.