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Chemotherapy of a malignant, metastasizing giant‐cell tumor of bone. Report of an unusual case and the response to combination chemotherapy
Author(s) -
Mella Olav,
Dahl Olav,
Bang Gisle,
Engedal Hogne,
Gøthlin Jan,
Lunde Ole D.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820715)50:2<207::aid-cncr2820500206>3.0.co;2-n
Subject(s) - medicine , vincristine , cyclophosphamide , chemotherapy , doxorubicin , methotrexate , thoracotomy , surgery , combination chemotherapy , giant cell , lung , pathology
A 13‐year‐old girl was treated surgically for a giant‐cell tumor of bone originating in the talus and for a recurrence in the distal tibia. She later developed liver and lung metastases and was treated for two years, five months with a combination of vincristine, doxorubicin, cyclophosphamide and actinomycin‐D, and thereafter with high‐dose methotrexate/vincristine with citrovorum factor rescue. A good response was obtained and the patient is without evidence of disease 12 months after a salvage thoracotomy for residual disease in the left lung. Aspects of this singular case are discussed.