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An Original hypercalcemic infantile renal tumor without bone metastasis: Heterotransplantation to nude mice report of two cases
Author(s) -
RousseauMerck M. F.,
BocconGibod L.,
Nogues C.,
Lesec G.,
Lenoir G.,
Chatelet F.,
Avril S.,
Nezelof C.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820701)50:1<85::aid-cncr2820500116>3.0.co;2-h
Subject(s) - medicine , pathology , ultrastructure , bone metastasis , cancer , metastasis , endocrinology
Two cases of hypercalcemic infantile renal tumor without macroscopic bone metastases are reported. Optical and ultrastructural characteristics as well as biological and clinical data are sufficiently different from those of other infantile renal tumors to justify the individualization of an original tumor entity. The hypercalcemia is not clearly understood but may be related, in one case, with a high N terminal PTH serum level. Ultrastructural elements (secretory granules) and polypeptide hormone products (glucagon) are discussed in relation with APUD cells characteristics. Cancer 50:85–93, 1982.