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Mitomycin‐C, methotrexate, bleomycin and cis‐diamminedichloroplatinum II in the chemotherapy of advanced squamous cancer of the head and neck
Author(s) -
Vogl Steven E.,
Lerner Harvey,
Kaplan Barry H.,
Camacho Fernando,
Cinberg James,
Schoenfeld David
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820701)50:1<6::aid-cncr2820500103>3.0.co;2-h
Subject(s) - medicine , bleomycin , methotrexate , regimen , mitomycin c , complete response , chemotherapy , head and neck cancer , cancer , surgery , head and neck , toxicity , radiation therapy , oncology , gastroenterology
Abstract Thirty‐four patients with advanced squamous cancer of the head and neck were treated with an outpatient regimen combining mitomycin‐C, cis‐diamminedichloroplatinum (II), methotrexate and bleomycin. Five had complete remissions and 15 partial remissions, for an overall response rate of 59%. Responses were noted in 11 of 13 patients (85%) with disease above the clavicles without prior irradiation. Median duration of partial remission was four months. Response rate was independent of age, performance status, presence of distant metastases and primary site. Hematologic toxicity was substantially more severe with this program than had been observed in a prior study using the same regimen without mitomycin‐C. Since neither complete nor partial response rates, nor response durations improved with the addition of mitomycin, we conclude that it adds little to the efficacy of the other three agents.