Premium
Gastrin‐secreting tumor of the duodenum (G‐cell apudoma) associated with secondary biliary cirrhosis
Author(s) -
Lee William M.,
Silva Fred,
Price John B.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820615)49:12<2596::aid-cncr2820491231>3.0.co;2-6
Subject(s) - medicine , duodenum , gastroenterology , cholestasis , ampulla of vater , primary biliary cirrhosis , cirrhosis , biliary cirrhosis , ampulla , general surgery , carcinoma , disease , autoimmune disease
A middle‐aged woman with evidence of chronic cholestasis of several years and no previous abdominal surgery was initially thought to have primary biliary cirrhosis. Clinical evaluation disclosed a well‐developed secondary biliary cirrhosis apparently caused by extrahepatic obstruction due to a 1 × 2 cm neoplasm of the periampullary duodenum. Electron microscopy and immunofluorescent studies showed the neoplasm to be a G‐cell adenoma. Wide local excision has resolved the biliary obstruction. Benign or slow‐growing duodenal tumors, if they involve the ampulla of Vater, may produce prolonged partial extrahepatic obstruction and secondary biliary cirrhosis.