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Alpha‐1‐antitrypsin deficiency in Southern African hepatocellular carcinoma patients: An immunoperoxidase and histochemical study
Author(s) -
Cohen Cynthia,
Berson Solomon D.,
Budgeon Lynn R.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820615)49:12<2537::aid-cncr2820491222>3.0.co;2-7
Subject(s) - hepatocellular carcinoma , diastase , immunoperoxidase , pathology , medicine , lobules of liver , alpha 1 antitrypsin deficiency , autopsy , alpha (finance) , staining , etiology , gastroenterology , immunology , surgery , antibody , monoclonal antibody , construct validity , patient satisfaction
An increased frequency of alpha‐1‐antitrypsin deficiency (AATD) has been reported in patients with hepatocellular carcinoma (HCC) in Scandinavia and England. Using a specific immunoperoxidase technique for alpha‐1‐antitrypsin (AAT) and periodic acid‐Schiff (PAS) with and without diastase predigestion, the authors examined nonneoplastic autopsy liver tissue from 58 black southern African patients with HCC and from 54 controls. No periportal PAS‐positive diastase‐resistant globules containing AAT (specific for AATD) were found in liver tissue from either group. A finely granular diffuse cytoplasmic AAT staining (not removed by diastase predigestion) was present in hepatocytes in a “checkerboard” pattern within the lobule in 33 (57%) HCC patients and in 20 (37%) controls ( P > 0.1), and was particularly prominent adjacent to tumor in 11 HCC patients. Alpha‐1‐antitrypsin was present in neoplastic cells in 18 of the 40 HCC examined (45%). These findings suggest no major role for AATD in the etiology of HCC in southern Africa.