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Relationships between steroid receptor and epithelial cell proliferation in benign fibrocystic disease of the breast
Author(s) -
Jacquemier Jocelyne D.,
Rolland Pierre H.,
Vague Daniele,
Lieutaud Roger,
Spitalier Jean M.,
Martin Pierre M.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820615)49:12<2534::aid-cncr2820491221>3.0.co;2-j
Subject(s) - hyperplasia , medicine , fibrocystic disease , estrogen receptor , pathology , fibrocystic breast disease , breast disease , estrogen , mammary gland , progestin , progesterone receptor , breast cancer , cancer
Tissue specimens from 27 patients with mammary fibrocystic disease were assayed for estrogen (ER) and progestin (PR) receptors. Seventeen patients (63%) had ER‐positive lesions (>5 fmol/mg protein). A progression in ER presence was noted from fibrocystic disease (33%) and fibrosing adenosis (50%) to lobular and ductal hyperplasia (85%). Similarly, ER content increased from 14.5 ± 13 fmol/mg cytosol protein in fibrocystic disease and fibrosing adenosis to 31.5 ± 23 fmol/mg protein in epithelial hyperplastic lesions. Furthermore, the ER‐PR couple was only encountered in lobular and ductal hyperplasia. The authors' data indicate that the incidence of steroid receptor parallels the intensity of hyperplasia in benign breast disease.