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Idiopathic acquired sideroblastic anemia terminating in acute myelosclerosis
Author(s) -
Butler William M.,
Taylor H. Grant,
Viswanathan Uma
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820615)49:12<2497::aid-cncr2820491215>3.0.co;2-x
Subject(s) - medicine , hepatosplenomegaly , pancytopenia , sideroblastic anemia , myelofibrosis , anemia , acute leukemia , bone marrow , pediatrics , leukemia , disease
Acute myelosclerosis is an unusual myeloproliferative syndrome characterized by pancytopenia, absence of massive hepatosplenomegaly, and an absence of tear‐drop poikilocytes. The marrow is usually fibrotic with atypical megakaryocytic proliferation and trilinear dyspoiesis. Median survival is approximately six months from onset of symptoms. The authors report a case of acute myelosclerosis that evolved in a patient two and one‐half years after the onset of idiopathic acquired sideroblastic anemia. A review of the other previously reported case of this unusual transformation and comments on the pathogenesis of the transformation from idiopathic acquired sideroblastic anemia to acute myelofibrosis are included.