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Disappearance rate of endogenously radioiodinated thyroglobulin and thyroxine after radioiodine treatment
Author(s) -
Jeevanram R. K.,
Shah D. H.,
Sharma S. M.,
Ganatra R. D.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820601)49:11<2281::aid-cncr2820491113>3.0.co;2-1
Subject(s) - medicine , thyroglobulin , endocrinology , radioiodine therapy , thyroid , thyroid cancer
Endogenously radioiodinated thyroglobulin (tg) and thyroxine (T 4 ), in the circulation following, therapeutic doses of radioiodine were studied in five patients with differentiated thyroid carcinoma. Radioactive serum was fractionated on a Sephadex G‐200 and the various radioactive peaks thus obtained were analyzed for their biochemical and immunologic characteristics using precipitation with trichloroacetic acid (TCA) and antithyroglobulin antibody extraction with acidified n‐butanol and electrophoresis on agar gel. The disappearance rates of endogenously labelled tg and T 4 were 3.12 ± 0.396 days and 10.14 ± 1.81 days, respectively.