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Intracranial ependymoma: Results of radiotherapy at the University of Kentucky
Author(s) -
Chin H. W.,
Maruyama Y.,
Markesbery W.,
Young A. B.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820601)49:11<2276::aid-cncr2820491112>3.0.co;2-r
Subject(s) - ependymoma , medicine , radiation therapy , survival rate , surgery
Sixteen patients with intracranial ependymoma received radiation treatment at the Department of Radiation Medicine, University of Kentucky, between 1962 and 1974. The majority of intracranial tumors occurred in children and had an infratentorial location; most adult tumors were supratentorial and adults had a greater tendency for high‐grade malignant tumors. The overall five‐year survival rate was 37% with 50% failure within three years. Survival appeared to be closely related to grade of tumor. Therefore, tumors were classified as ependymoma (well‐differentiated) or ependymoblastoma (anaplastic, poorly differentiated). Five‐year survival rate in patients with ependymoma tumors was 71% and with ependymoblastoma 11%. The data and a literature review indicate that radical radiotherapy of the ependymoma produces good patient survival; the ependymoblastoma is not adequately controlled with radical radiotherapy alone and adjuvant therapy may be necessary.