Premium
Effect of age at first childbirth on risk of developing specific histologic subtype of breast cancer
Author(s) -
Livolsi Virginia A.,
Kelsey Jennifer L.,
Fischer Diana B.,
Holford Theodore R.,
Mostow Evelyn D.,
Goldenberg Ira S.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820501)49:9<1937::aid-cncr2820490931>3.0.co;2-h
Subject(s) - medicine , childbirth , breast cancer , obstetrics , cancer , gynecology , oncology , pregnancy , biology , genetics
Epidemiologic variables related to breast cancer risk were assessed in a case‐control study of 332 women with breast carcinoma and 1353 comparison women. Risk factors for breast cancer as a whole included nulliparity, late age at first childbirth, early age at menarche, late age at menopause, personal history of benign breast disease, family history of breast cancer, and among postmenopausal women, body weight. These risk factors were then analyzed with respect to histologic subtype of breast cancer involved, i.e. , duct‐derived or lobular tumors, to determine whether the association between any of the risk factors and breast cancer varied according to histopathologic subtype. Histologic subtype for the 316 cases reviewed included 284 duct cancers and 32 lobular carcinomas. Although slight differences were noted among some of the risk factors and the variety of cancer, none of the differences was marked except for the variable age at first birth. For ductal carcinoma, the risk was highest among nulliparous women and decreased the younger a woman was at the time she gave birth to her first child. The risk of infiltrating lobular carcinoma, however, was lowest among nulliparous females or those who had given birth at a young age and increased the older a woman was when she gave birth to her first child.