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Intestinal mucinous substances in gastric intestinal metaplasia and carcinoma studied by immunofluorescence
Author(s) -
Ma Jeng,
De Boer Willem G. R. M.,
Nayman Jacob
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820415)49:8<1664::aid-cncr2820490822>3.0.co;2-o
Subject(s) - medicine , intestinal metaplasia , immunofluorescence , pathology , carcinoma , mucinous carcinoma , gastric carcinoma , gastroenterology , adenocarcinoma , stomach , cancer , antibody , immunology
Immunofluorescent studies using specific antisera against intestinal mucins revealed small intestinal mucin antigen (SIMA) and large intestinal mucin antigen (LIMA) in areas of intestinal metaplasia of the stomach. In 25 gastric carcinomas studied, both these antigens were detected in seven carcinomas, SIMA only was present in four and LIMA only in four cases; the antigens could not be detected in ten of the carcinomas. In 21 of the 25 gastric cancer operation specimens, including the 15 carcinomas positive for intestinal mucin antigens, there was evidence of chronic gastritis and intestinal metaplasia. These immunohistologic observations confirm the results of recent histochemical studies that both small and large intestinal type mucins are present in intestinal metaplasia and gastric carcinomas. 1,2 Our findings provide further evidence that at least a proportion of gastric carcinomas may supervene on intestinal metaplasia. The absence of one or both antigens in gastric carcinomas may indicate stages of dedifferentiation or alternatively differences in histogenesis.