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Prolymphocytic leukemia: Treatment with combination chemotherapy to include doxorubicin
Author(s) -
Taylor H. Grant,
Butler William M.,
Rhoads Joanne,
Karcher Donald S.,
DetrickHooks Barbara
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820415)49:8<1524::aid-cncr2820490803>3.0.co;2-u
Subject(s) - medicine , prolymphocytic leukemia , vincristine , chronic lymphocytic leukemia , chemotherapy , leukemia , doxorubicin , prednisone , cyclophosphamide , splenectomy , oncology , spleen
Prolymphocytic leukemia (PL) is a clinically distinct leukemic disorder. Cytochemical and surface marker characteristics help to differentiate PL from other types of leukemia, including chronic lym‐phocytic leukemia (CLL). In contrast to patients with CLL, those with PL frequently require early therapeutic intervention. Standard treatment regimens for CLL as well as splenectomy and splenic irradiation have not been effective in the treatment of PL. Combination chemotherapy with cyclo‐phosphamide, Doxorubicin, vincristine, and prednisone (CHOP) has produced impressive clinical responses in patients with PL. The treatment of a patient with PL is discussed and the literature is reviewed.