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Medulloblastoma in adults. Improved survival with supervoltage radiation therapy
Author(s) -
Kopelson Gene,
Linggood Rita M.,
Kleinman George M.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820401)49:7<1334::aid-cncr2820490704>3.0.co;2-c
Subject(s) - medicine , medulloblastoma , posterior fossa , radiation therapy , overall survival , fossa , survival rate , surgery , pathology
During the period from January 1962‐June 1979, 17 adults (⩾16 years of age) received postoperative supervoltage neuraxis radiation therapy for medulloblastoma. An actuarial five‐ and ten‐year survival rate of 46% was achieved, and the major site of recurrence postirradiation was in the posterior fossa. Compared to previous pediatric series, adults may demonstrate more visceral metastases and fare less well after tumor recurrence. Compared to prior series of adult patients, the demonstrated improved survival is attributed to increased doses delivered to the posterior fossa.