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Megakaryoblastic transformation of chronic myelogenous leukemia
Author(s) -
Williams William C.,
Weiss Gary B.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820301)49:5<921::aid-cncr2820490516>3.0.co;2-w
Subject(s) - chronic myelogenous leukemia , medicine , megakaryocyte , philadelphia chromosome , leukemia , acute megakaryoblastic leukemia , polycythemia vera , transformation (genetics) , immunology , haematopoiesis , chromosomal translocation , stem cell , genetics , biology , gene
A 52‐year‐old man with Ph 1 ‐positive chronic myelogenous leukemia (CML) developed a blastic transformation in which the predominant cell type was micromegakaryocytes. He did not respond to treatment. A review of the 15 previously reported cases of patients with circulating megakaryocyte abnormalities in association with either CML or a Ph 1 chromosome positive myeloproliferative disorder suggests a female predominance rather than the usual male predominance of CML. Survival of the six patients reported as megakaryoblastic transformation of CML as well as this patient was poor.