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Effective multidrug, multimodality consolidation therapy of adult acute lymphocytic leukemia: A preliminary report
Author(s) -
Stein Richard S.,
Flexner John M.,
Collins Robert D.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820301)49:5<846::aid-cncr2820490504>3.0.co;2-p
Subject(s) - medicine , vincristine , prednisone , cyclophosphamide , acute lymphocytic leukemia , regimen , leukemia , methotrexate , cytarabine , chop , lymphoma , gastroenterology , oncology , surgery , chemotherapy , lymphoblastic leukemia
Twelve of 13 adult patients with acute lymphocytic leukemia, acute undifferentiated leukemia, or convoluted T‐cell lymphoma (T‐cell ALL) who were treated with Adriamycin, vincristine, and prednisone achieved a complete remission. An intensive consolidation regimen was administered. This regimen included Cytosine Arabinoside, L‐asparaginase, and multiple courses of CHOP (cyclophosphamide, Adriamycin, vincristine, and prednisone). In addition, cranial irradiation and intrathecal methotrexate were administered. By actuarial estimate, 81% of previously untreated patients who achieved a complete remission will remain in remission for more than two years.