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Lymphomas and leukemias in the relatives of patients with mycosis fungoides
Author(s) -
Greene Mark H.,
Pinto Harlan A.,
Kant Jeffrey A.,
Siler Kathleen,
Vonderheid Eric C.,
Lamberg Stanford I.,
Dalager Nancy A.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820215)49:4<737::aid-cncr2820490423>3.0.co;2-r
Subject(s) - mycosis fungoides , medicine , lymphoma , lymphoproliferative disorders , multiple myeloma , disease , pathology , dermatology , oncology , immunology , cancer research
Of 526 consecutive patients with cutaneous T‐cell lymphomas, 21 had first‐degree relatives with lymphoproliferative or hematopoietic malignancies. Twenty‐nine such tumors occurred in the 21 kindreds. Hodgkin's disease accounted for one‐third of this total, with various leukemias (11 cases), non‐Hodgkin's lymphoma (five cases), and multiple myeloma (three cases) comprising the remainder. These data suggest that genetically‐determined immunoregulatory abnormalities may represent a shared pathway of oncogenesis in diverse lymphoproliferative and hematopoietic malignancies.