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Ultrastructural studies of xenografted human germ cell tumors
Author(s) -
Monaghan Paul,
Raghavan Derek,
Neville A. Munro
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820215)49:4<683::aid-cncr2820490417>3.0.co;2-q
Subject(s) - histogenesis , yolk sac , ultrastructure , seminoma , pathology , embryonal carcinoma , germ cell tumors , germ cell , carcinoma , biology , medicine , embryo , cellular differentiation , immunohistochemistry , microbiology and biotechnology , chemotherapy , gene , biochemistry
Xenografts have been established in immune‐suppressed mice from three embryonal cell carcinomas, two yolk sac carcinomas, and a ‘seminoma‐like’ tumor that produces alphafetoprotein. The ultrastructural features of these xenografts have been studied in detail and compared with human germ cell tumors removed from patients. A spectrum of ultrastructural differentiation has been demonstrated for tumors of the same histologic classification (embryonal cell carcinoma) and within individual tumors. Cells with ultrastructural appearances intermediate between seminoma and yolk sac carcinoma and between embryonal cell and yolk sac carcinoma have been demonstrated, and their potential implications for tumor histogenesis are discussed.