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Hepatitis B antigen in the liver in hepatocellular carcinoma in shikoku, Japan
Author(s) -
Akagi Go,
Furuya Keizo,
Otsuka Hisashi
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820215)49:4<678::aid-cncr2820490416>3.0.co;2-f
Subject(s) - medicine , hbsag , hepatocellular carcinoma , cirrhosis , gastroenterology , autopsy , hepatitis , orcein , stain , hepatitis b , pathology , carcinoma , hepatitis b virus , staining , immunology , virus
An analysis of 105 autopsy cases (77 male, 28 female) of hepatocellular carcinoma (HCC) showed that 90 cases (85.7%) were associated with liver cirrhosis, of which 75 cases (83.3%) were of the macronodular type. Hepatitis B surface antigen (HBsAg) was detected with orcein stain in the hepatic tissue in 58 cases (55.2%). The incidence of HBsAg in cases of HCC patients with cirrhosis (58.9%) was higher, but not significantly, than that in those without cirrhosis (33.3%). The mean age of HBsAg‐positive cases was five years less than that of HBsAg‐negative cases, the age distributions therefore being significantly different.