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Fatal misonidazole‐induced encephalopathy. An RTOG case report
Author(s) -
Kun Larry E.,
Ho KhangCheng,
Moulder John E.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820201)49:3<423::aid-cncr2820490305>3.0.co;2-l
Subject(s) - medicine , encephalopathy , misonidazole , anorexia , toxic encephalopathy , toxicity , central nervous system , anesthesia , neurotoxicity , necrosis , dehydration , pathology , biochemistry , chemistry , in vitro
A case of fatal encephalopathy following administration of misonidazole (MISO) is reported. Anorexia and dehydration preceded signs of encephalopathy after a cumulative dose of 18 g (11 g/m 2 ) of MISO in five weekly doses. Serum MISO levels four hours after weekly administrations were markedly elevated. Postmortem examination revealed focal cortical neuronal necrosis and hemorrhage with focal demyelination. The possible relationship of dehydration or altered drug metabolism to the development of MISO central nervous system toxicity is noted.