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Monoclonal immunoglobulins with affinity for platelets and their relationship to malignant lymphoma
Author(s) -
Veenhoven W. A.,
Thomas Schans G. S. Van Der,
Nieweg H. O.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820101)49:1<40::aid-cncr2820490110>3.0.co;2-3
Subject(s) - medicine , thrombocytopenic purpura , lymphoma , monoclonal antibody , platelet , antibody , chronic lymphocytic leukemia , cancer , leukemia , immunology
Monoclonal immunoglobulins with affinity for platelets were detected in the blood of seven patients. Two of these had thrombocytopenia and non‐Hodkin's lymphoma (NHL). One patient had thrombocytopenia and possibly incipient NHL. The other four patients had pseudothrombocytopenia at the time of diagnosis but one of them developed NHL six years later. It is suggested that these monoclonal immunoglobulins may in some cases be associated with malignant lymphoma and that subjects presenting with these immunoglobulins should have a long term follow‐up in order to elucidate the question whether or not lymphoma will develop.