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Effect of ultrasound‐induced hyperthermia and cis‐diamminedichloride platinum II on murine renal function
Author(s) -
Elkon D.,
Lacher D. A.,
Rinehart L.,
Wills M. R.,
Savory J.,
Constable W. C.,
Baker D. G.
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820101)49:1<25::aid-cncr2820490106>3.0.co;2-a
Subject(s) - medicine , hyperthermia , renal function , ultrasound , urology , platinum , cancer research , radiology , biochemistry , chemistry , catalysis
Murine renal function was evaluated after ultrasound‐induced kidney hyperthermia (42.5°C and 46,5%deg; C for 35 minutes) and the administration of cis‐diamminedichloride platinum II (8 mg/kg). A quantitative immunonephelometric technique was employed to determine urinary total protein (TP) and albumin (Alb) 1–180 days post‐treatment. Hyperthermia of 46.5°C elevated urinary TP excretion significantly more than that of 42.5°C cis‐diamminedichloride platinum (Cis DDP) administration greatly increased urine TP with a peak mean TP concentration of 488 μg/ml, four days after Cis DDP (normal range was 26–48 μg/ml). This returned to normal by day 14. The TP excretion after 42.5°C hyperthermia with concurrent Cis DDP was similar to Cis DDP alone, implying there was no potentiation of early or late Cis‐DDP‐induced renal damage by hyperthermia. Late mouse mortality was greater ( P = 0.08) after Cis DDP alone, than Cis DDP with 42.5°C hyperthermia. There was a statistically significant increase ( P < 0.05) in the Alb/TP exccetion ratio after the addition of 42.5°C hyperthermia to Cis DDP, implying an alteration in the site or nature of the Cis DDP renal lesion by hyperthermia.