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Successful treatment of metastatic extragonadal endodermal sinus (Yolk Sac) tumor in childhood
Author(s) -
Thomas William J.,
Kelleher John F.,
DuvalArnould Bertrand
Publication year - 1981
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19811201)48:11<2371::aid-cncr2820481106>3.0.co;2-#
Subject(s) - endodermal sinus tumor , medicine , vinblastine , bleomycin , chemotherapy , yolk sac , regimen , doxorubicin , metastasis , combination chemotherapy , oncology , surgery , cancer , embryo , germ cell tumors , biology , microbiology and biotechnology
Two children with metastatic extragonadal endodermal sinus tumor who had failed VAC chemotherapy were treated with combination chemotherapy consisting of cis‐platinum, vinblastine, doxorubicin HCI (Adriamycin) and bleomycin (cis‐VAB). There was a complete response in both patients with one child remaining tumor‐free 3½ years after metastasis and 2½ years after stopping therapy. The main toxic reactions encountered were associated with the use of cis‐platinum, but these were manageable and resolved upon completion of therapy. Cis‐VAB appears to be a safe and effective regimen for the treatment of metastatic endodermal sinus tumor. A study of the efficacy of cis‐VAB in a larger group of children with endodermal sinus tumor of poor prognosis seems indicated.